| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Erlin-2 (50-150) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S1MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ERLIN2 |
| Gene ID: |
11160 |
| Uniprot ID: |
ERLN2_HUMAN |
| Immunogen Region: |
50-150 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Erlin-2 (O94905). |
| Immunogen Sequence: |
HLMLPFITSYKSVQTTLQTD EVKNVPCGTSGGVMIYFDRI EVVNFLVPNAVYDIVKNYTA DYDKALIFNKIHHELNQFCS VHTLQEVYIELFDQIDENLK L |
| Tissue Specificity | Ubiquitous. |
| Function | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex. |
| Protein Name | Erlin-2Endoplasmic Reticulum Lipid Raft-Associated Protein 2Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 2Spfh Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-382556Reactome: R-HSA-5655302Reactome: R-HSA-5678895Reactome: R-HSA-8853336 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinAssociated With Lipid Raft-Like Domains Of The Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Erlin-2 antibodyAnti-Endoplasmic Reticulum Lipid Raft-Associated Protein 2 antibodyAnti-Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 2 antibodyAnti-Spfh Domain-Containing Protein 2 antibodyAnti-ERLIN2 antibodyAnti-C8orf2 antibodyAnti-SPFH2 antibodyAnti-UNQ2441 antibodyAnti-PRO5003 antibodyAnti-PRO9924 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of various lysates using [KO Validated] IRF3 Rabbit monoclonal antibody (STJ11101781) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3min.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/90696/360781/STJ11101781_1__59011.1713125500.jpg?c=1 "Western blot analysis of various lysates using [KO Validated] IRF3 Rabbit monoclonal antibody (STJ11101781) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3min.")