Anti-EREG antibody (C-Term) (STJ118800)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal EREG (C-Term) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | EREG |
| Gene ID | 2069 |
| Uniprot ID | EREG_HUMAN |
| Immunogen Region | C-Term |
| Immunogen Sequence | SDMNGYCLHGQCIYLVDMSQ NYCRCEVGYTGVRCEHFFLT VHQPLSKEYVALTVILIILF LITVVGSTYYFCRWYRNRKS KEPKKEYERVTSGDPELPQV |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 70-169 of human EREG (NP_001423.1). |
Additional Info
| Tissue Specificity | In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon. |
| Function | Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation. Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation. |
| Protein Name | Proepiregulin Cleaved Into - EpiregulinEpr |
| Database Links | Reactome: R-HSA-1227986Reactome: R-HSA-1236394Reactome: R-HSA-1250196Reactome: R-HSA-1250342Reactome: R-HSA-1250347Reactome: R-HSA-1251985Reactome: R-HSA-1257604Reactome: R-HSA-177929Reactome: R-HSA-179812Reactome: R-HSA-180292Reactome: R-HSA-180336Reactome: R-HSA-182971Reactome: R-HSA-1963640Reactome: R-HSA-1963642Reactome: R-HSA-212718Reactome: R-HSA-2219530Reactome: R-HSA-5638303Reactome: R-HSA-5673001Reactome: R-HSA-6785631Reactome: R-HSA-6811558Reactome: R-HSA-8847993Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8863795Reactome: R-HSA-9009391Reactome: R-HSA-9634638Reactome: R-HSA-9664565Reactome: R-HSA-9665686 |
| Cellular Localisation | Epiregulin: SecretedExtracellular SpaceProepiregulin: Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Proepiregulin Cleaved Into - Epiregulin antibodyAnti-Epr antibodyAnti-EREG antibody |
Information sourced from Uniprot.org