| Function | Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the sites of RNA polymerase II-blocking lesions. Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation.DNA-dependent ATPase activity is essential for this function. Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle. Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing the premature exit from the G2/M checkpoint. Acts as a chromatin remodeler at DSBs.DNA-dependent ATPase-dependent activity is essential for this function. Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR. Required for stable recruitment of ELOA and CUL5 to DNA damage sites. Involved in UV-induced translocation of ERCC8 to the nuclear matrix. Essential for neuronal differentiation and neuritogenesis.regulates transcription and chromatin remodeling activities required during neurogenesis. |
| Protein Name | Dna Excision Repair Protein Ercc-6Atp-Dependent Helicase Ercc6Cockayne Syndrome Protein Csb |
| Database Links | Reactome: R-MMU-5250924Reactome: -MMU-6781823Reactome: -MMU-6782135Reactome: -MMU-6782210Reactome: -MMU-73762 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dna Excision Repair Protein Ercc-6 antibodyAnti-Atp-Dependent Helicase Ercc6 antibodyAnti-Cockayne Syndrome Protein Csb antibodyAnti-Ercc6 antibodyAnti-Csb antibody |
Information sourced from Uniprot.org
