| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ERC1 |
| Gene ID: |
23085 |
| Uniprot ID: |
RB6I2_HUMAN |
| Immunogen Region: |
700-850 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 700-850 of human ERC1 (NP_829884.1). |
| Immunogen Sequence: |
EIALEQKKEECLKMESQLKK AHEAALEARASPEMSDRIQH LEREITRYKDESSKAQAEVD RLLEILKEVENEKNDKDKKI AELERQVKDQNKKVANLKHK EQVEKKKSAQMLEEARRRED NLNDSSQQLQDSLRKKDDRI EELEEALRESV |
| Tissue Specificity | Widely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested. |
| Function | Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. |
| Protein Name | Elks/Rab6-Interacting/Cast Family Member 1Erc-1Rab6-Interacting Protein 2 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeMembranePeripheral Membrane ProteinGolgi Apparatus MembranePresynaptic Cell MembraneCell ProjectionPodosomeRecruited On Golgi Membranes By Rab6a In A Gtp-Dependent MannerLocalized To The Cortex Of Myotube Podosomes |
| Alternative Antibody Names | Anti-Elks/Rab6-Interacting/Cast Family Member 1 antibodyAnti-Erc-1 antibodyAnti-Rab6-Interacting Protein 2 antibodyAnti-ERC1 antibodyAnti-ELKS antibodyAnti-KIAA1081 antibodyAnti-RAB6IP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
