| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ERAP2 |
| Gene ID: | 64167 |
| Uniprot ID: | ERAP2_HUMAN |
| Immunogen Region: | 1-170 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human ERAP2 (NP_071745.1). |
| Immunogen Sequence: | MFHSSAMVNSHRKPMFNIHR GFYCLTAILPQICICSQFSV PSSYHFTEDPGAFPVATNGE RFPWQELRLPSVVIPLHYDL FVHPNLTSLDFVASEKIEVL VSNATQFIILHSKDLEITNA TLQSEEDSRYMKPGKELKVL SYPAHEQIALLVPEKLTPHL KYYVAMDFQA |
| Tissue Specificity | Ubiquitously expressed. Highly expressed in spleen and leukocytes. |
| Post Translational Modifications | N-glycosylated. |
| Function | Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys. |
| Protein Name | Endoplasmic Reticulum Aminopeptidase 2Leukocyte-Derived Arginine AminopeptidaseL-Rap |
| Database Links | Reactome: R-HSA-983170 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Endoplasmic Reticulum Aminopeptidase 2 antibodyAnti-Leukocyte-Derived Arginine Aminopeptidase antibodyAnti-L-Rap antibodyAnti-ERAP2 antibodyAnti-LRAP antibody |
Information sourced from Uniprot.org