| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-ERAP1 (842-941) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S2MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ERAP1 |
| Gene ID: |
51752 |
| Uniprot ID: |
ERAP1_HUMAN |
| Immunogen Region: |
842-941 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 842-941 of human ERAP1 (Q9NZ08). |
| Immunogen Sequence: |
NPVGYPLAWQFLRKNWNKLV QKFELGSSSIAHMVMGTTNQ FSTRTRLEEVKGFFSSLKEN GSQLRCVQQTIETIEENIGW MDKNFDKIRVWLQSEKLERM |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | N-glycosylated. |
| Function | Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. |
| Protein Name | Endoplasmic Reticulum Aminopeptidase 1Arts-1Adipocyte-Derived Leucine AminopeptidaseA-LapAminopeptidase PilsPuromycin-Insensitive Leucyl-Specific AminopeptidasePils-ApType 1 Tumor Necrosis Factor Receptor Shedding Aminopeptidase Regulator |
| Database Links | Reactome: R-HSA-983170 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Endoplasmic Reticulum Aminopeptidase 1 antibodyAnti-Arts-1 antibodyAnti-Adipocyte-Derived Leucine Aminopeptidase antibodyAnti-A-Lap antibodyAnti-Aminopeptidase Pils antibodyAnti-Puromycin-Insensitive Leucyl-Specific Aminopeptidase antibodyAnti-Pils-Ap antibodyAnti-Type 1 Tumor Necrosis Factor Receptor Shedding Aminopeptidase Regulator antibodyAnti-ERAP1 antibodyAnti-APPILS antibodyAnti-ARTS1 antibodyAnti-KIAA0525 antibodyAnti-UNQ584 antibodyAnti-PRO1154 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
