| Host: |
Rabbit |
| Applications: |
WB/ICC/IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-EPS15R (2-15 aa) is suitable for use in Western Blot, Immunocytochemistry and Immunofluorescence research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
R05-8A0 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Purification: |
Affinity Purified |
| Concentration: |
0.3 mg/ml |
| Dilution Range: |
WB 1:500-1:1000IF 1:50-1:200 |
| Storage Instruction: |
Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: |
EPS15L1 |
| Gene ID: |
58513 |
| Uniprot ID: |
EP15R_HUMAN |
| Immunogen Region: |
2-15 aa |
| Immunogen: |
A synthetic peptide of human EPS15R |
| Post Translational Modifications | Phosphorylated on tyrosine residues by EGFR. |
| Function | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. |
| Protein Name | Epidermal Growth Factor Receptor Substrate 15-Like 1Eps15-Related ProteinEps15r |
| Database Links | Reactome: R-HSA-182971Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinNucleusMembraneCoated PitLocalized To Plasma Membrane Coated Pits |
| Alternative Antibody Names | Anti-Epidermal Growth Factor Receptor Substrate 15-Like 1 antibodyAnti-Eps15-Related Protein antibodyAnti-Eps15r antibodyAnti-EPS15L1 antibodyAnti-EPS15R antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
