Immunocytochemistry analysis of EPS15R (green) in Hela using EPS15R antibody, and DAPI (blue).

Anti-EPS15L1 antibody (2-15 aa) [R05-8A0] (STJA0012365)

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STJA0012365-100
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: WB/ICC/IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-EPS15R (2-15 aa) is suitable for use in Western Blot, Immunocytochemistry and Immunofluorescence research applications.
Clonality : Monoclonal
Clone ID : R05-8A0
Conjugation: Unconjugated
Isotype: IgG
Formulation: 50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Purification: Affinity Purified
Concentration: 0.3 mg/ml
Dilution Range: WB 1:500-1:1000
IF 1:50-1:200
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: EPS15L1
Gene ID: 58513
Uniprot ID: EP15R_HUMAN
Immunogen Region: 2-15 aa
Immunogen: A synthetic peptide of human EPS15R
Post Translational Modifications Phosphorylated on tyrosine residues by EGFR.
Function Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Protein Name Epidermal Growth Factor Receptor Substrate 15-Like 1
Eps15-Related Protein
Eps15r
Database Links Reactome: R-HSA-182971
Reactome: R-HSA-8856825
Reactome: R-HSA-8856828
Cellular Localisation Cell Membrane
Peripheral Membrane Protein
Nucleus
Membrane
Coated Pit
Localized To Plasma Membrane Coated Pits
Alternative Antibody Names Anti-Epidermal Growth Factor Receptor Substrate 15-Like 1 antibody
Anti-Eps15-Related Protein antibody
Anti-Eps15r antibody
Anti-EPS15L1 antibody
Anti-EPS15R antibody

Information sourced from Uniprot.org

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