Anti-Epithelial Keratin Type I antibody [AE-1] (STJ16100261)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenHuman epidermal keratin
General Information
| Short Description | Mouse monoclonal anti-Epithelial Keratin Type I for use in IHC-P, IHC-F and WB in Human, Mouse, Rabbit, Rat, Bovine and Chicken samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P/IHC-F/WB |
| Host | Mouse |
| Reactivity | Human/Mouse/Rabbit/Rat/Bovine/Chicken |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AE-1 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Dilution Range | IHC-P 1:150-1:200IHC-F 1:150-1:200WB 1:100 |
| Formulation | PBS with 0.1% sodium azide |
| Storage Instruction | Store at 2-8ยฐC for up to 1-year, upon receipt. |
Target Information
| Immunogen | Human epidermal keratin |
Additional Info
| Background | Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa-68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. |
Information sourced from Uniprot.org