| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4114RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EPHX2 |
| Gene ID: | 2053 |
| Uniprot ID: | HYES_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human EPHX2 (P34913). |
| Immunogen Sequence: | MTLRAAVFDLDGVLALPAVF GVLGRTEEALALPRGLLNDA FQKGGPEGATTRLMKGEITL SQWIPLMEENCRKCSETAKV CLPKNFSIKEIFDKAISARK |
| Post Translational Modifications | The N-terminus is blocked. The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation (Probable). |
| Function | Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. Bifunctional enzyme. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid. Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates. |
| Protein Name | Bifunctional Epoxide Hydrolase 2 Includes - Cytosolic Epoxide Hydrolase 2 Ceh Epoxide Hydratase Soluble Epoxide Hydrolase Seh - Lipid-Phosphate Phosphatase |
| Database Links | Reactome: R-HSA-2142670 Reactome: R-HSA-9018682 Reactome: R-HSA-9033241 |
| Cellular Localisation | Cytoplasm Peroxisome |
| Alternative Antibody Names | Anti-Bifunctional Epoxide Hydrolase 2 Includes - Cytosolic Epoxide Hydrolase 2 antibody Anti-Ceh antibody Anti-Epoxide Hydratase antibody Anti-Soluble Epoxide Hydrolase antibody Anti-Seh - Lipid-Phosphate Phosphatase antibody Anti-EPHX2 antibody |
Information sourced from Uniprot.org