Anti-Ephrin Receptor B1 antibody (850-900) {Biotin} (STJ500931)

SKU:
STJ500931-100

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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Ephrin Receptor B1 (850-900) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.58 µg/µl
Dilution Range: WB: 1:750
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:100
IHC: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Ephb1
Gene ID: 270190
Uniprot ID: EPHB1_MOUSE
Immunogen Region: 850-900
Immunogen: Synthetic peptide taken within amino acid region 850-900 on mouse Eph BR1 protein.
Tissue Specificity Expressed in neural stem and progenitor cells in the dentate gyrus. Expressed in myogenic progenitor cells.
Post Translational Modifications Phosphorylated. Autophosphorylation is stimulated by the ligand EFNB1. Required for interaction with SH2 domain-containing interactors, for activation of the MAPK/ERK and JUN signaling cascades and for ubiquitination by CBL. Ubiquitinated.(EFNB1)ligand-induced poly- and/or multi-ubiquitination by CBL is regulated by SRC and leads to lysosomal degradation.
Function Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation.
Protein Name Ephrin Type-B Receptor 1
Database Links Reactome: R-MMU-2682334
Reactome: -MMU-3928662
Reactome: -MMU-3928664
Reactome: -MMU-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Early Endosome Membrane
Cell Projection
Dendrite
Alternative Antibody Names Anti-Ephrin Type-B Receptor 1 antibody
Anti-Ephb1 antibody

Information sourced from Uniprot.org

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