Immunohistochemistry analysis of paraffin-embedded human lymph node (left) and brain (right) , showing cytoplasmic localization with DAB staining using EphB6 monoclonal antibody.

Anti-EPHB6 antibody (601-750 aa) [2A6B9] (STJ98038)

SKU:
STJ98038
£144.00 - £348.00
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Covered by St John's Laboratory Guarantee

Host: Mouse
Applications: WB/IHC/IF/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Ephrin type-B receptor 6 (601-750 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality : Monoclonal
Clone ID : 2A6B9
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC 1:200-1:1000
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EPHB6
Gene ID: 2051
Uniprot ID: EPHB6_HUMAN
Immunogen Region: 601-750 aa
Specificity: EphB6 Monoclonal Antibody detects endogenous levels of EphB6 protein.
Immunogen: Purified recombinant fragment of EphB6 (aa601-750) expressed in E. Coli.
Post Translational Modifications Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion.
Function Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
Protein Name Ephrin Type-B Receptor 6
Hep
Tyrosine-Protein Kinase-Defective Receptor Eph-6
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928662
Reactome: R-HSA-3928664
Reactome: R-HSA-3928665
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Isoform 3: Secreted
Alternative Antibody Names Anti-Ephrin Type-B Receptor 6 antibody
Anti-Hep antibody
Anti-Tyrosine-Protein Kinase-Defective Receptor Eph-6 antibody
Anti-EPHB6 antibody

Information sourced from Uniprot.org

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