• Western blot analysis of lysates from Jurkat and 293 cells, using EPHB4 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of HY926 cells using EphB4 Polyclonal Antibody diluted at 1：2000

Anti-EPHB4 antibody (571-620 aa) (STJ92952)

SKU:
STJ92952

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Ephrin type-B receptor 4 (571-620 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EPHB4
Gene ID: 2050
Uniprot ID: EPHB4_HUMAN
Immunogen Region: 571-620 aa
Specificity: EphB4 Polyclonal Antibody detects endogenous levels of EphB4 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human EPHB4 at the amino acid range 571-620
Post Translational Modifications Phosphorylated.autophosphorylation is stimulated by EFNB2.
Function Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells.
Protein Name Ephrin Type-B Receptor 4
Hepatoma Transmembrane Kinase
Tyrosine-Protein Kinase Tyro11
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928662
Reactome: R-HSA-3928664
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Ephrin Type-B Receptor 4 antibody
Anti-Hepatoma Transmembrane Kinase antibody
Anti-Tyrosine-Protein Kinase Tyro11 antibody
Anti-EPHB4 antibody
Anti-HTK antibody
Anti-MYK1 antibody
Anti-TYRO11 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance