• Western blot analysis of lysates from Jurkat cells and COLO205 cells, using EPHA7 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of the lysates from HeLa cells using EPHA7 antibody.
  • Western blot analysis of 293T-UV cells using EphA7 Polyclonal Antibody diluted at 1：500

Anti-EPHA7 antibody (451-500 aa) (STJ92946)

SKU:
STJ92946

€57.50 - €282.50
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Ephrin type-A receptor 7 (451-500 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EPHA7
Gene ID: 2045
Uniprot ID: EPHA7_HUMAN
Immunogen Region: 451-500 aa
Specificity: EphA7 Polyclonal Antibody detects endogenous levels of EphA7 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human EPHA7 at the amino acid range 451-500
Post Translational Modifications Phosphorylated.
Function Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7.
Protein Name Ephrin Type-A Receptor 7
Eph Homology Kinase 3
Ehk-3
Eph-Like Kinase 11
Ek11
Hek11
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928663
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Ephrin Type-A Receptor 7 antibody
Anti-Eph Homology Kinase 3 antibody
Anti-Ehk-3 antibody
Anti-Eph-Like Kinase 11 antibody
Anti-Ek11 antibody
Anti-Hek11 antibody
Anti-EPHA7 antibody
Anti-EHK3 antibody
Anti-HEK11 antibody

Information sourced from Uniprot.org

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