Anti-EPHA5 antibody (600-700) {FITC} (STJ500920)

SKU:
STJ500920-100

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Host: Rabbit
Applications: ELISA/WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EPHA5 (600-700) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.55-0.75 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: EPHA5
Gene ID: 2044
Uniprot ID: EPHA5_HUMAN
Immunogen Region: 600-700
Immunogen: Synthetic peptide taken within amino acid region 600-700 on human EphA R5 protein.
Tissue Specificity Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord.
Post Translational Modifications Phosphorylated. Phosphorylation is stimulated by the ligand EFNA5. Dephosphorylation upon stimulation by glucose, inhibits EPHA5 forward signaling and results in insulin secretion.
Function Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion.
Protein Name Ephrin Type-A Receptor 5
Brain-Specific Kinase
Eph Homology Kinase 1
Ehk-1
Eph-Like Kinase 7
Ek7
Hek7
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928663
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Axon
Dendrite
Alternative Antibody Names Anti-Ephrin Type-A Receptor 5 antibody
Anti-Brain-Specific Kinase antibody
Anti-Eph Homology Kinase 1 antibody
Anti-Ehk-1 antibody
Anti-Eph-Like Kinase 7 antibody
Anti-Ek7 antibody
Anti-Hek7 antibody
Anti-EPHA5 antibody
Anti-BSK antibody
Anti-EHK1 antibody
Anti-HEK7 antibody
Anti-TYRO4 antibody

Information sourced from Uniprot.org

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