| Host: | Rabbit |
| Applications: | ELISA/IP/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-EPHA1 (55-605) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Biotin |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.5 µg/µl |
| Dilution Range: | WB: 1:500 ELISA: 1:10, 000 IP: 1:200 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | EPHA1 |
| Gene ID: | 2041 |
| Uniprot ID: | EPHA1_HUMAN |
| Immunogen Region: | 55-605 |
| Immunogen: | Synthetic peptide taken within amino acid region 55-605 on human Ephrin type-A receptor 1. |
| Tissue Specificity | Overexpressed in several carcinomas. |
| Post Translational Modifications | Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1. Ubiquitinated. |
| Function | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. |
| Protein Name | Ephrin Type-A Receptor 1 Hepha1 Eph Tyrosine Kinase Eph Tyrosine Kinase 1 Erythropoietin-Producing Hepatoma Receptor Tyrosine-Protein Kinase Receptor Eph |
| Database Links | Reactome: R-HSA-2682334 Reactome: R-HSA-2892247 Reactome: R-HSA-3928663 Reactome: R-HSA-3928665 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Ephrin Type-A Receptor 1 antibody Anti-Hepha1 antibody Anti-Eph Tyrosine Kinase antibody Anti-Eph Tyrosine Kinase 1 antibody Anti-Erythropoietin-Producing Hepatoma Receptor antibody Anti-Tyrosine-Protein Kinase Receptor Eph antibody Anti-EPHA1 antibody Anti-EPH antibody Anti-EPHT antibody Anti-EPHT1 antibody |
Information sourced from Uniprot.org