| Host: | Mouse |
| Applications: | ELISA/FC/IF/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Epithelial Cell Adhesion Molecule is suitable for use in ELISA, Flow Cytometry, Immunofluorescence and Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | C52 |
| Conjugation: | PerCP |
| Isotype: | IgG2ak |
| Formulation: | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. |
| Purification: | Purified |
| Concentration: | 0.5 mg/mL |
| Storage Instruction: | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| Gene Symbol: | EPCAM |
| Gene ID: | 4072 |
| Uniprot ID: | EPCAM_HUMAN |
| Post Translational Modifications | Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability. |
| Function | May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. |
| Protein Name | Epithelial Cell Adhesion MoleculeEp-CamAdenocarcinoma-Associated AntigenCell Surface Glycoprotein Trop-1Epithelial Cell Surface AntigenEpithelial GlycoproteinEgpEpithelial Glycoprotein 314Egp314Hegp314Ks 1/4 AntigenKsaMajor Gastrointestinal Tumor-Associated Protein Ga733-2Tumor-Associated Calcium Signal Transducer 1Cd Antigen Cd326 |
| Database Links | Reactome: R-HSA-202733 |
| Cellular Localisation | Lateral Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionTight JunctionColocalizes With Cldn7 At The Lateral Cell Membrane And Tight Junction |
| Alternative Antibody Names | Anti-Epithelial Cell Adhesion Molecule antibodyAnti-Ep-Cam antibodyAnti-Adenocarcinoma-Associated Antigen antibodyAnti-Cell Surface Glycoprotein Trop-1 antibodyAnti-Epithelial Cell Surface Antigen antibodyAnti-Epithelial Glycoprotein antibodyAnti-Egp antibodyAnti-Epithelial Glycoprotein 314 antibodyAnti-Egp314 antibodyAnti-Hegp314 antibodyAnti-Ks 1/4 Antigen antibodyAnti-Ksa antibodyAnti-Major Gastrointestinal Tumor-Associated Protein Ga733-2 antibodyAnti-Tumor-Associated Calcium Signal Transducer 1 antibodyAnti-Cd Antigen Cd326 antibodyAnti-EPCAM antibodyAnti-GA733-2 antibodyAnti-M1S2 antibodyAnti-M4S1 antibodyAnti-MIC18 antibodyAnti-TACSTD1 antibodyAnti-TROP1 antibody |
Information sourced from Uniprot.org