| Tissue Specificity | Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues. |
| Post Translational Modifications | N-glycosylated.high-mannose type. Glycosylation is not essential for enzymatic activity. |
| Function | Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP. In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER. |
| Protein Name | Nucleoside Diphosphate Phosphatase Entpd5Cd39 Antigen-Like 4Er-UdpaseEctonucleoside Triphosphate Diphosphohydrolase 5Ntpdase 5Guanosine-Diphosphatase Entpd5Gdpase Entpd5Inosine Diphosphate Phosphatase Entpd5Nucleoside DiphosphataseUridine-Diphosphatase Entpd5Udpase Entpd5 |
| Database Links | Reactome: R-HSA-8850843Reactome: R-HSA-9660826 |
| Cellular Localisation | Endoplasmic ReticulumSecreted |
| Alternative Antibody Names | Anti-Nucleoside Diphosphate Phosphatase Entpd5 antibodyAnti-Cd39 Antigen-Like 4 antibodyAnti-Er-Udpase antibodyAnti-Ectonucleoside Triphosphate Diphosphohydrolase 5 antibodyAnti-Ntpdase 5 antibodyAnti-Guanosine-Diphosphatase Entpd5 antibodyAnti-Gdpase Entpd5 antibodyAnti-Inosine Diphosphate Phosphatase Entpd5 antibodyAnti-Nucleoside Diphosphatase antibodyAnti-Uridine-Diphosphatase Entpd5 antibodyAnti-Udpase Entpd5 antibodyAnti-ENTPD5 antibodyAnti-CD39L4 antibodyAnti-PCPH antibody |
Information sourced from Uniprot.org
