| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ENTPD1 |
| Gene ID: | 953 |
| Uniprot ID: | ENTP1_HUMAN |
| Immunogen Region: | 1-180 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human ENTPD1/CD39 (NP_001157655.1). |
| Immunogen Sequence: | MESEELADRVLDVVERSLSN YPFDFQGARIITGQEEGAYG WITINYLLGKFSQKTRWFSI VPYETNNQETFGALDLGGAS TQVTFVPQNQTIESPDNALQ FRLYGKDYNVYTHSFLCYGK DQALWQKLAKDIQVASNEIL RDPCFHPGYKKVVNVSDLYK TPCTKRFEMTLPFQQFEIQG |
| Tissue Specificity | Expressed primarily on activated lymphoid cells. Also expressed in endothelial tissues. Highly expressed in placenta, lung, skeletal muscle, kidney. |
| Post Translational Modifications | N-glycosylated. The N-terminus is blocked. Palmitoylated on Cys-13.which is required for caveola targeting. |
| Function | Catalyzes the hydrolysis of both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates and participates in the regulation of extracellular levels of nucleotides (Probable). By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow. |
| Protein Name | Ectonucleoside Triphosphate Diphosphohydrolase 1 Atp Diphosphohydrolase Atp-Dph Atpdase Ecto-Atp Diphosphohydrolase 1 Ecto-Atpdase 1 Ecto-Atpase 1 Ecto-Apyrase Lymphoid Cell Activation Antigen Nucleoside Triphosphate Diphosphohydrolase 1 Ntpdase1 Cd Antigen Cd39 |
| Database Links | Reactome: R-HSA-8850843 Reactome: R-HSA-9660826 |
| Cellular Localisation | Membrane Multi-Pass Membrane Protein Caveola |
| Alternative Antibody Names | Anti-Ectonucleoside Triphosphate Diphosphohydrolase 1 antibody Anti-Atp Diphosphohydrolase antibody Anti-Atp-Dph antibody Anti-Atpdase antibody Anti-Ecto-Atp Diphosphohydrolase 1 antibody Anti-Ecto-Atpdase 1 antibody Anti-Ecto-Atpase 1 antibody Anti-Ecto-Apyrase antibody Anti-Lymphoid Cell Activation Antigen antibody Anti-Nucleoside Triphosphate Diphosphohydrolase 1 antibody Anti-Ntpdase1 antibody Anti-Cd Antigen Cd39 antibody Anti-ENTPD1 antibody Anti-CD39 antibody |
Information sourced from Uniprot.org