Anti-ENPP4 antibody (90-230) (STJ116245)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ENPP4 (90-230) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ENPP4 |
| Gene ID | 22875 |
| Uniprot ID | ENPP4_HUMAN |
| Immunogen Region | 90-230 |
| Immunogen Sequence | ANSMYDAVTKKHFSDSNDKD PFWWNEAVPIWVTNQLQENR SSAAAMWPGTDVPIHDTISS YFMNYNSSVSFEERLNNITM WLNNSNPPVTFATLYWEEPD ASGHKYGPEDKENMSRVLKK IDDLIGDLVQRLKMLGLWEN L |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 90-230 of human ENPP4 (NP_055751.1). |
Additional Info
| Tissue Specificity | Expressed on the surface of vascular endothelia. |
| Function | Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors. |
| Protein Name | Bis(5'-Adenosyl-Triphosphatase Enpp4Ap3a HydrolaseAp3aaseEctonucleotide Pyrophosphatase/Phosphodiesterase Family Member 4E-Npp 4Npp-4 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Bis(5'-Adenosyl-Triphosphatase Enpp4 antibodyAnti-Ap3a Hydrolase antibodyAnti-Ap3aase antibodyAnti-Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 4 antibodyAnti-E-Npp 4 antibodyAnti-Npp-4 antibodyAnti-ENPP4 antibodyAnti-KIAA0879 antibodyAnti-NPP4 antibody |
Information sourced from Uniprot.org