| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (281-330 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:100-300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ENPP3 |
| Gene ID: |
5169 |
| Uniprot ID: |
ENPP3_HUMAN |
| Immunogen Region: |
281-330 aa |
| Specificity: |
CD203c Polyclonal Antibody detects endogenous levels of CD203c protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the Internal region of human ENPP3 at the amino acid range 281-330 |
| Post Translational Modifications | N-glycosylated. N-glycosylation is necessary for normal transport to the cell membrane, but is not the apical targeting signal. |
| Function | Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has a broad specificity and can also hydrolyze UDP-GlcNAc into UMP and GlcNAc-1-phosphate and potentially several other intracellular nucleotide sugars, including UDP-GalNAc, CMP-NeuAc, GDP-Fuc, and UDP-GlcA. Thereby, could modulate glycan biosynthesis and protein glycosylation. Can hydrolyze extracellular dinucleoside polyphosphates, including the vasoactive adenosine polyphosphates as well. In addition, displays an alkaline phosphodiesterase activity in vitro. |
| Protein Name | Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3E-Npp 3Npp3Alkaline Phosphodiesterase IDinucleoside PolyphosphataseNucleotide DiphosphataseNucleotide PyrophosphataseNppasePhosphodiesterase I BetaPd-IbetaPhosphodiesterase I/Nucleotide Pyrophosphatase 3Cd Antigen Cd203c |
| Database Links | Reactome: R-HSA-199220 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinApical Cell MembraneSecretedDetected At The Cell Surface Of BasophilsDetected At The Apical Plasma Membrane Of Bile Duct CellsLocated To The Apical Surface In Intestinal And Kidney Epithelial CellsSecreted In SerumAnd In Lumen Of Epithelial Cells |
| Alternative Antibody Names | Anti-Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3 antibodyAnti-E-Npp 3 antibodyAnti-Npp3 antibodyAnti-Alkaline Phosphodiesterase I antibodyAnti-Dinucleoside Polyphosphatase antibodyAnti-Nucleotide Diphosphatase antibodyAnti-Nucleotide Pyrophosphatase antibodyAnti-Nppase antibodyAnti-Phosphodiesterase I Beta antibodyAnti-Pd-Ibeta antibodyAnti-Phosphodiesterase I/Nucleotide Pyrophosphatase 3 antibodyAnti-Cd Antigen Cd203c antibodyAnti-ENPP3 antibodyAnti-PDNP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
