| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ENG |
| Gene ID: |
2022 |
| Uniprot ID: |
EGLN_HUMAN |
| Immunogen Region: |
26-658 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 26-337 of human CD105/Endoglin (NP_001108225.1). |
| Immunogen Sequence: |
ETVHCDLQPVGPERGEVTYT TSQVSKGCVAQAPNAILEVH VLFLEFPTGPSQLELTLQAS KQNGTWPREVLLVLSVNSSV FLHLQALGIPLHLAYNSSLV TFQEPPGVNTTELPSFPKTQ ILEWAAERGPITSAAELNDP QSILLRLGQAQGSLSFCMLE ASQDMGRTLEWRPRTPALVR GCHLEGVAGHKEAHILRVLP GHSAGPRTVTVKVELSCAPG DLDAVLILQGPPYVSWLID |
| Tissue Specificity | Detected on umbilical veil endothelial cells. Detected in placenta (at protein level). Detected on endothelial cells. |
| Function | Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3. |
| Protein Name | EndoglinCd Antigen Cd105 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Endoglin antibodyAnti-Cd Antigen Cd105 antibodyAnti-ENG antibodyAnti-END antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
