| Tissue Specificity | Skeletal muscle, heart, colon, testis, ovary and pancreas. |
| Post Translational Modifications | Found in four different phosphorylated forms, three of which appear to be associated with the cell cycle. |
| Function | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. |
| Protein Name | Emerin |
| Database Links | Reactome: R-HSA-2980766Reactome: R-HSA-2995383Reactome: R-HSA-4419969Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013408Reactome: R-HSA-9013423Reactome: R-HSA-9609523 |
| Cellular Localisation | Nucleus Inner MembraneSingle-Pass Membrane ProteinNucleoplasmic SideNucleus Outer MembraneColocalized With Banf1 At The Central Region Of The Assembling Nuclear RimNear Spindle-Attachment SitesThe Accumulation Of Different Intermediates Of Prelamin-A/C (Non-Farnesylated Or Carboxymethylated Farnesylated Prelamin-A/C) In Fibroblasts Modify Its Localization In The Nucleus |
| Alternative Antibody Names | Anti-Emerin antibodyAnti-EMD antibodyAnti-EDMD antibodyAnti-STA antibody |
Information sourced from Uniprot.org
![Anti-Emerin antibody [4G5] (STJ16101736)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/152242/347092/STJ16101736_1__93546.1681999356.png?c=1 "Anti-Emerin antibody [4G5] (STJ16101736)")
![Anti-Emerin antibody [4G5] (STJ16101736)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/152242/347092/STJ16101736_1__93546.1681999356.png?c=1 "Anti-Emerin antibody [4G5] (STJ16101736)")
