| Function | Non-catalytic subunit of the structure-specific, heterodimeric DNA endonuclease MUS81-EME1 which is involved in the maintenance of genome stability. In the complex, EME1 is required for DNA cleavage, participating in DNA recognition and bending. MUS81-EME1 cleaves 3'-flaps and nicked Holliday junctions, and exhibit limited endonuclease activity with 5' flaps and nicked double-stranded DNAs. Active during prometaphase, MUS81-EME1 resolves mitotic recombination intermediates, including Holliday junctions, which form during homologous recombination. |
| Protein Name | Structure-Specific Endonuclease Subunit Eme1Crossover Junction Endonuclease Eme1Essential Meiotic Structure-Specific Endonuclease 1Mms4 HomologHmms4 |
| Database Links | Reactome: R-HSA-5693568Reactome: R-HSA-6783310 |
| Cellular Localisation | NucleusNucleolusRecruited To Regions Of Dna Damage In S-Phase Cells |
| Alternative Antibody Names | Anti-Structure-Specific Endonuclease Subunit Eme1 antibodyAnti-Crossover Junction Endonuclease Eme1 antibodyAnti-Essential Meiotic Structure-Specific Endonuclease 1 antibodyAnti-Mms4 Homolog antibodyAnti-Hmms4 antibodyAnti-EME1 antibodyAnti-MMS4 antibody |
Information sourced from Uniprot.org
