| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
EME1 |
| Gene ID: |
146956 |
| Uniprot ID: |
EME1_HUMAN |
| Immunogen Region: |
1-320 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human EME1 (NP_689676.2). |
| Immunogen Sequence: |
MALKKSSPSLDSGDSDSEEL PTFAFLKKEPSSTKRRQPER EEKIVVVDISDCEASCPPAP ELFSPPVPEIAETVTQTQPV RLLSSESEDEEEFIPLAQRL TCKFLTHKQLSPEDSSSPVK SVLDHQNNEGASCDWKKPFP KIPEVPLHDTPERSAADNKD LILDPCCQLPAYLSTCPGQS SSLAVTKTNSDILPPQKKTK PSQKVQGRGSHGCRQQRQAR QKESTLRRQERKNAALVTR |
| Function | Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. |
| Protein Name | Crossover Junction Endonuclease Eme1Mms4 HomologHmms4 |
| Database Links | Reactome: R-HSA-5693568Reactome: R-HSA-6783310 |
| Cellular Localisation | NucleusNucleolusRecruited To Regions Of Dna Damage In S-Phase Cells |
| Alternative Antibody Names | Anti-Crossover Junction Endonuclease Eme1 antibodyAnti-Mms4 Homolog antibodyAnti-Hmms4 antibodyAnti-EME1 antibodyAnti-MMS4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
