Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | EME1 |
Gene ID: | 146956 |
Uniprot ID: | EME1_HUMAN |
Immunogen Region: | 1-320 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human EME1 (NP_689676.2). |
Immunogen Sequence: | MALKKSSPSLDSGDSDSEEL PTFAFLKKEPSSTKRRQPER EEKIVVVDISDCEASCPPAP ELFSPPVPEIAETVTQTQPV RLLSSESEDEEEFIPLAQRL TCKFLTHKQLSPEDSSSPVK SVLDHQNNEGASCDWKKPFP KIPEVPLHDTPERSAADNKD LILDPCCQLPAYLSTCPGQS SSLAVTKTNSDILPPQKKTK PSQKVQGRGSHGCRQQRQAR QKESTLRRQERKNAALVTR |
Function | Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. |
Protein Name | Crossover Junction Endonuclease Eme1Mms4 HomologHmms4 |
Database Links | Reactome: R-HSA-5693568Reactome: R-HSA-6783310 |
Cellular Localisation | NucleusNucleolusRecruited To Regions Of Dna Damage In S-Phase Cells |
Alternative Antibody Names | Anti-Crossover Junction Endonuclease Eme1 antibodyAnti-Mms4 Homolog antibodyAnti-Hmms4 antibodyAnti-EME1 antibodyAnti-MMS4 antibody |
Information sourced from Uniprot.org