Anti-EMC4 antibody (91-141 aa) (STJ197816)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human EMC4 at the amino acid range 91-141
General Information
| Short Description | Rabbit polyclonal anti-ER membrane protein complex subunit 4 (91-141 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | EMC4 |
| Gene ID | 51234 |
| Uniprot ID | EMC4_HUMAN |
| Immunogen | Synthesized peptide derived from the human EMC4 at the amino acid range 91-141 |
| Immunogen Region | 91-141 aa |
| Specificity | This antibody detects endogenous levels of human EMC4 |
Additional Info
| Function | Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). |
| Protein Name | Er Membrane Protein Complex Subunit 4Cell Proliferation-Inducing Gene 17 ProteinTransmembrane Protein 85 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinCould Also Be A Single-Pass Transmembrane Protein With Cytosolic N-Terminus And Lumenal C-Terminus |
| Alternative Antibody Names | Anti-Er Membrane Protein Complex Subunit 4 antibodyAnti-Cell Proliferation-Inducing Gene 17 Protein antibodyAnti-Transmembrane Protein 85 antibodyAnti-EMC4 antibodyAnti-TMEM85 antibodyAnti-HSPC184 antibodyAnti-PIG17 antibody |
Information sourced from Uniprot.org