| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ELMO2 |
| Gene ID: | 63916 |
| Uniprot ID: | ELMO2_HUMAN |
| Immunogen Region: | 42-120 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 42-120 of human ELMO2 (NP_877496.1). |
| Immunogen Sequence: | SLPNPEYYTLRYADGPQLYI TEQTRSDIKNGTILQLAISP SRAARQLMERTQSSNMETRL DAMKELAKLSADVTFATEF |
| Tissue Specificity | Widely expressed, with a higher expression in skeletal muscle, kidney and placenta. |
| Function | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. |
| Protein Name | Engulfment And Cell Motility Protein 2Protein Ced-12 Homolog AHced-12a |
| Database Links | Reactome: R-HSA-2029482Reactome: R-HSA-4420097Reactome: R-HSA-8849471Reactome: R-HSA-9013408Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmCytosolMembrane |
| Alternative Antibody Names | Anti-Engulfment And Cell Motility Protein 2 antibodyAnti-Protein Ced-12 Homolog A antibodyAnti-Hced-12a antibodyAnti-ELMO2 antibodyAnti-CED12A antibodyAnti-KIAA1834 antibody |
Information sourced from Uniprot.org