Anti-ELMO1 antibody (527-727) (STJ117030)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ELMO1 (527-727) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ELMO1 |
| Gene ID | 9844 |
| Uniprot ID | ELMO1_HUMAN |
| Immunogen Region | 527-727 |
| Immunogen Sequence | DFQSRPILELKEKIQPEILE LIKQQRLNRLVEGTCFRKLN ARRRQDKFWYCRLSPNHKVL HYGDLEESPQGEVPHDSLQD KLPVADIKAVVTGKDCPHMK EKGALKQNKEVLELAFSILY DSNCQLNFIAPDKHEYCIWT DGLNALLGKDMMSDLTRNDL DTLLSMEIKLRLLDLENIQI PDAPPPIPKEPSNYDFVYDC N |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 527-727 of human ELMO1 (NP_055615.8). |
Additional Info
| Tissue Specificity | Widely expressed, with a higher expression in the spleen and placenta. |
| Post Translational Modifications | Phosphorylated by HCK. |
| Function | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. |
| Protein Name | Engulfment And Cell Motility Protein 1Protein Ced-12 Homolog |
| Database Links | Reactome: R-HSA-164944Reactome: R-HSA-2029482Reactome: R-HSA-4420097Reactome: R-HSA-8849471Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmCell MembraneTranslocation To Plasma Membrane Seems To Be Mediated By Dock1 And Crk |
| Alternative Antibody Names | Anti-Engulfment And Cell Motility Protein 1 antibodyAnti-Protein Ced-12 Homolog antibodyAnti-ELMO1 antibodyAnti-KIAA0281 antibody |
Information sourced from Uniprot.org