Anti-ELANE antibody (30-267) (STJ114982)

Name: Anti-ELANE antibody (30-267) (STJ114982)
SKU: STJ114982
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ114982

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Short Description	Rabbit polyclonal ELANE (30-267) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	ELANE
Gene ID	1991
Uniprot ID	ELNE_HUMAN
Immunogen Region	30-267
Immunogen Sequence	IVGGRRARPHAWPFMVSLQL RGGHFCGATLIAPNFVMSAA HCVANVNVRAVRVVLGAHNL SRREPTRQVFAVQRIFENGY DPVNLLNDIVILQLNGSATI NANVQVAQLPAQGRRLGNGV QCLAMGWGLLGRNRGIASVL QELNVTVVTSLCRRSNVCTL VRGRQAGVCFGDSGSPLVCN GLIHGIASFVRGGCASGLYP DAFAPVAQFVNWIDSIIQRS EDNPCPHPRDPDPASRTH
Specificity	A synthetic peptide corresponding to a sequence within amino acids 30-267 of human Neutrophil Elastase (ELANE) (NP_001963.1).

Tissue Specificity	Bone marrow cells. Neutrophil.
Function	Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Promotes cleavage of GSDMB, thereby inhibiting pyroptosis. Promotes blood coagulation. Through the activation of the platelet fibrinogen receptor integrin alpha-IIb/beta-3, potentiates platelet aggregation induced by a threshold concentration of cathepsin G (CTSG). Cleaves and thus inactivates tissue factor pathway inhibitor (TFPI). Capable of killing E.coli but not S.aureus in vitro.digests outer membrane protein A (ompA) in E.coli and K.pneumoniae.
Protein Name	Neutrophil Elastase Bone Marrow Serine Protease Elastase-2 Human Leukocyte Elastase Hle Medullasin Pmn Elastase
Database Links	Reactome: R-HSA-1442490 Reactome: R-HSA-1474228 Reactome: R-HSA-1592389 Reactome: R-HSA-5620971 Reactome: R-HSA-6798695 Reactome: R-HSA-6803157 Reactome: R-HSA-977606 Reactome: R-HSA-9911233
Cellular Localisation	Cytoplasmic Vesicle Phagosome Localized In Phagolysosomes Following Ingestion Of E Coli By Neutrophils
Alternative Antibody Names	Anti-Neutrophil Elastase antibody Anti-Bone Marrow Serine Protease antibody Anti-Elastase-2 antibody Anti-Human Leukocyte Elastase antibody Anti-Hle antibody Anti-Medullasin antibody Anti-Pmn Elastase antibody Anti-ELANE antibody Anti-ELA2 antibody

Information sourced from Uniprot.org