| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Phosphorylation by MAPK8/JNK1 and or MAPK9/JNK2 in response to oxidative stress promotes P-body assembly. Phosphorylated during meiotic maturation. |
| Function | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation. Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis. Promotes miRNA-mediated translational repression. Required for the formation of P-bodies. Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay. Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism. |
| Protein Name | Eukaryotic Translation Initiation Factor 4e Transporter4e-TEif4e TransporterEukaryotic Translation Initiation Factor 4e Nuclear Import Factor 1 |
| Cellular Localisation | CytoplasmP-BodyNucleusPml BodyNucleus SpecklePredominantly CytoplasmicMainly Localizes To Processing Bodies (P-Bodies)Shuttles Between The Nucleus And The Cytoplasm In A Crm1-Dependent MannerLocalization To Nuclear Foci And Speckles Requires Active Transcription |
| Alternative Antibody Names | Anti-Eukaryotic Translation Initiation Factor 4e Transporter antibodyAnti-4e-T antibodyAnti-Eif4e Transporter antibodyAnti-Eukaryotic Translation Initiation Factor 4e Nuclear Import Factor 1 antibodyAnti-EIF4ENIF1 antibody |
Information sourced from Uniprot.org
