| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-EIF4ENIF1 (150-250) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
EIF4ENIF1 |
| Gene ID: |
56478 |
| Uniprot ID: |
4ET_HUMAN |
| Immunogen Region: |
150-250 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human EIF4ENIF1 (NP_001157973.1). |
| Immunogen Sequence: |
LGGRRIGSGRIISARTFEKD HRLSDKDLRDLRDRDRERDF KDKRFRREFGDSKRVFGERR RNDSYTEEEPEWFSAGPTSQ SETIELTGFDDKILEEDHKG R |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Phosphorylation by MAPK8/JNK1 and or MAPK9/JNK2 in response to oxidative stress promotes P-body assembly. Phosphorylated during meiotic maturation. |
| Function | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation. Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis. Promotes miRNA-mediated translational repression. Required for the formation of P-bodies. Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay. Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism. |
| Protein Name | Eukaryotic Translation Initiation Factor 4e Transporter4e-TEif4e TransporterEukaryotic Translation Initiation Factor 4e Nuclear Import Factor 1 |
| Cellular Localisation | CytoplasmP-BodyNucleusPml BodyNucleus SpecklePredominantly CytoplasmicMainly Localizes To Processing Bodies (P-Bodies)Shuttles Between The Nucleus And The Cytoplasm In A Crm1-Dependent MannerLocalization To Nuclear Foci And Speckles Requires Active Transcription |
| Alternative Antibody Names | Anti-Eukaryotic Translation Initiation Factor 4e Transporter antibodyAnti-4e-T antibodyAnti-Eif4e Transporter antibodyAnti-Eukaryotic Translation Initiation Factor 4e Nuclear Import Factor 1 antibodyAnti-EIF4ENIF1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
