| Host: | Mouse |
| Applications: | WB |
| Reactivity: | Transfected |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Eukaryotic translation initiation factor 4E-binding protein 3 is suitable for use in Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 3B6-D3-H7 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EIF4EBP3 |
| Gene ID: | 8637 |
| Uniprot ID: | 4EBP3_HUMAN |
| Specificity: | Transfected Only. |
| Immunogen: | Recombinant protein of human EIF4EBP3. |
| Post Translational Modifications | Phosphorylated. |
| Function | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: the hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repression of translation. In contrast, the hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Inhibits EIF4E-mediated mRNA nuclear export. |
| Protein Name | Eukaryotic Translation Initiation Factor 4e-Binding Protein 34e-Bp3Eif4e-Binding Protein 3 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Eukaryotic Translation Initiation Factor 4e-Binding Protein 3 antibodyAnti-4e-Bp3 antibodyAnti-Eif4e-Binding Protein 3 antibodyAnti-EIF4EBP3 antibody |
Information sourced from Uniprot.org