| Post Translational Modifications | Phosphorylation is enhanced upon serum stimulation. Phosphorylated during apoptosis by caspase-processed CDK11. |
| Function | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling. |
| Protein Name | Eukaryotic Translation Initiation Factor 3 Subunit FEif3fDeubiquitinating Enzyme Eif3fEukaryotic Translation Initiation Factor 3 Subunit 5Eif-3-EpsilonEif3 P47 |
| Database Links | Reactome: R-HSA-156827Reactome: R-HSA-72649Reactome: R-HSA-72689Reactome: R-HSA-72695Reactome: R-HSA-72702Reactome: R-HSA-72706 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Eukaryotic Translation Initiation Factor 3 Subunit F antibodyAnti-Eif3f antibodyAnti-Deubiquitinating Enzyme Eif3f antibodyAnti-Eukaryotic Translation Initiation Factor 3 Subunit 5 antibodyAnti-Eif-3-Epsilon antibodyAnti-Eif3 P47 antibodyAnti-EIF3F antibodyAnti-EIF3S5 antibody |
Information sourced from Uniprot.org
