| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Translation initiation factor eIF-2B subunit epsilon (480-560 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EIF2B5 |
| Gene ID: | 8893 |
| Uniprot ID: | EI2BE_HUMAN |
| Immunogen Region: | 480-560 aa |
| Specificity: | EI2BE Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 480-560 |
| Function | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed. |
| Protein Name | Translation Initiation Factor Eif2b Subunit EpsilonEif2b Gdp-Gtp Exchange Factor Subunit Epsilon |
| Database Links | Reactome: R-HSA-72731 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Translation Initiation Factor Eif2b Subunit Epsilon antibodyAnti-Eif2b Gdp-Gtp Exchange Factor Subunit Epsilon antibodyAnti-EIF2B5 antibodyAnti-EIF2BE antibody |
Information sourced from Uniprot.org