| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
EFNA5 |
| Gene ID: |
1946 |
| Uniprot ID: |
EFNA5_HUMAN |
| Immunogen Region: |
135-215 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 135-215 of human EFNA5 (NP_001953.1). |
| Immunogen Sequence: |
EYFYISSAIPDNGRRSCLKL KVFVRPTNSCMKTIGVHDRV FDVNDKVENSLEPADDTVHE SAEPSRGENAAQTPRIPSRL L |
| Function | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion. |
| Protein Name | Ephrin-A5Al-1Eph-Related Receptor Tyrosine Kinase Ligand 7Lerk-7 |
| Database Links | Reactome: R-HSA-2682334Reactome: R-HSA-3928663Reactome: R-HSA-3928665 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembraneCaveolaCompartmentalized In Discrete Caveolae-Like Membrane Microdomains |
| Alternative Antibody Names | Anti-Ephrin-A5 antibodyAnti-Al-1 antibodyAnti-Eph-Related Receptor Tyrosine Kinase Ligand 7 antibodyAnti-Lerk-7 antibodyAnti-EFNA5 antibodyAnti-EPLG7 antibodyAnti-LERK7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
