| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EFHC1 |
| Gene ID: | 114327 |
| Uniprot ID: | EFHC1_HUMAN |
| Immunogen Region: | 391-640 |
| Immunogen Sequence: | EDSAQNCFALIPKAPKKDVI KMLVNDNKVLRYLAVLESPI PEDKDRRFVFSYFLATDMIS IFEPPVRNSGIIGGKYLGRT KVVKPYSTVDNPVYYGPSDF FIGAVIEVFGHRFIILDTDE YVLKYMESNAAQYSPEALAS IQNHVRKREAPAPEAESKQT EKDPGVQELEALIDTIQKQL KDHSCKDNIREAFQIYDKEA SGYVDRDMFFKICESLNVPV DDSLVKELIRMCSHGEGKI |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 391-640 of human EFHC1 (NP_060570.2). |
| Tissue Specificity | Widely expressed. Not detected in lymphocytes. |
| Function | Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death. |
| Protein Name | Ef-Hand Domain-Containing Protein 1Myoclonin-1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCilium AxonemeFlagellum AxonemeMicrotubule Organizing CenterCentrosomeSpindleSpindle Pole |
| Alternative Antibody Names | Anti-Ef-Hand Domain-Containing Protein 1 antibodyAnti-Myoclonin-1 antibodyAnti-EFHC1 antibody |
Information sourced from Uniprot.org
