• Immunohistochemistry analysis of paraffin-embedded human placenta tissue, using EFEMP2 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of lysates from K562 and NIH/3T3 cells, using EFEMP2 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Immunofluorescence analysis of A549 cells, using EFEMP2 Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-EFEMP2 antibody (91-140 aa) (STJ93074)

SKU:
STJ93074

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EGF-containing fibulin-like extracellular matrix protein 2 (91-140 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EFEMP2
Gene ID: 30008
Uniprot ID: FBLN4_HUMAN
Immunogen Region: 91-140 aa
Specificity: Fibulin-4 Polyclonal Antibody detects endogenous levels of Fibulin-4 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human EFEMP2 at the amino acid range 91-140
Function Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta. In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin. Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction. Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling.
Protein Name Egf-Containing Fibulin-Like Extracellular Matrix Protein 2
Fibulin-4
Fibl-4
Protein Uph1
Database Links Reactome: R-HSA-2129379
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Basement Membrane
Localizes On The Microfibrils Surrounding Eln Cores
Alternative Antibody Names Anti-Egf-Containing Fibulin-Like Extracellular Matrix Protein 2 antibody
Anti-Fibulin-4 antibody
Anti-Fibl-4 antibody
Anti-Protein Uph1 antibody
Anti-EFEMP2 antibody
Anti-FBLN4 antibody
Anti-UNQ200 antibody
Anti-PRO226 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance