| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-EBI3 (130-229) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S2MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
EBI3 |
| Gene ID: |
10148 |
| Uniprot ID: |
IL27B_HUMAN |
| Immunogen Region: |
130-229 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 130-229 of human EBI3 (Q14213). |
| Immunogen Sequence: |
DPPEGVRLSPLAERQLQVQW EPPGSWPFPEIFSLKYWIRY KRQGAARFHRVGPIEATSFI LRAVRPRARYYVQVAAQDLT DYGELSDWSLPATATMSLGK |
| Function | Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. |
| Protein Name | Interleukin-27 Subunit BetaIl-27 Subunit BetaIl-27bEpstein-Barr Virus-Induced Gene 3 ProteinEbv-Induced Gene 3 Protein |
| Database Links | Reactome: R-HSA-8984722Reactome: R-HSA-9020956 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-27 Subunit Beta antibodyAnti-Il-27 Subunit Beta antibodyAnti-Il-27b antibodyAnti-Epstein-Barr Virus-Induced Gene 3 Protein antibodyAnti-Ebv-Induced Gene 3 Protein antibodyAnti-EBI3 antibodyAnti-IL27B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
