| Tissue Specificity | Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes. |
| Post Translational Modifications | Phosphorylated at Ser-236 by CK2 leading to enhanced cell adhesion. Phosphorylated by CDK1 and AURKB during mitosis reduces the binding affinity of MAPRE2 for microtubules. Ubiquitinated in an ASB14-dependent manner.leading to proteasomal degradation. |
| Function | Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability. Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation. Plays a role during oocyte meiosis by regulating microtubule dynamics. Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation. Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics. |
| Protein Name | Microtubule-Associated Protein Rp/Eb Family Member 2Apc-Binding Protein Eb2End-Binding Protein 2Eb2 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonAssociated With The Microtubule NetworkAccumulates At The Plus End Of Microtubules |
| Alternative Antibody Names | Anti-Microtubule-Associated Protein Rp/Eb Family Member 2 antibodyAnti-Apc-Binding Protein Eb2 antibodyAnti-End-Binding Protein 2 antibodyAnti-Eb2 antibodyAnti-MAPRE2 antibodyAnti-RP1 antibody |
Information sourced from Uniprot.org
