![Anti-Dystrophin antibody (N-Term) [DY10/12B2] (STJ16101731)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/152237/347089/STJ16101731_1__73414.1681999352.jpg?c=1 "Anti-Dystrophin antibody (N-Term) [DY10/12B2] (STJ16101731)")
![Anti-Dystrophin antibody (N-Term) [DY10/12B2] (STJ16101731)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/152237/347089/STJ16101731_1__73414.1681999352.jpg?c=1 "Anti-Dystrophin antibody (N-Term) [DY10/12B2] (STJ16101731)")
Anti-Dystrophin antibody (N-Term) [DY10/12B2] (STJ16101731)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
ImmunogenFusion protein containing amino acids 67 to 713.
General Information
| Short Description | Mouse monoclonal anti-Dystrophin (N-Term) for use in IHC-F in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-F |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | DY10/12B2 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Formulation | Lyophilized |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | DMD |
| Gene ID | 1756 |
| Uniprot ID | DMD_HUMAN |
| Immunogen | Fusion protein containing amino acids 67 to 713. |
| Immunogen Region | N-Term |
Additional Info
| Tissue Specificity | Expressed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma. Expressed in brain, muscle, kidney, lung and testis. Most tissues contain transcripts of multiple isoforms. Isoform 15: Only isoform to be detected in heart and liver and is also expressed in brain, testis and hepatoma cells. |
| Function | Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. |
| Protein Name | Dystrophin |
| Database Links | Reactome: R-HSA-3000171Reactome: R-HSA-390522Reactome: R-HSA-9913351 |
| Cellular Localisation | Cell MembraneSarcolemmaPeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonPostsynaptic Cell MembraneIn Muscle CellsSarcolemma Localization Requires The Presence Of Ank2While Localization To Costameres Requires The Presence Of Ank3Localizes To Neuromuscular Junctions (Nmjs)In Adult MuscleNmj Localization Depends Upon Ank2 PresenceBut Not In Newborn Animals |
| Alternative Antibody Names | Anti-Dystrophin antibodyAnti-DMD antibody |
Information sourced from Uniprot.org