| Post Translational Modifications | Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization. |
| Function | Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Plays an essential role in ribosomal DNA (rDNA) double-strand break repair and rDNA copy number maintenance. During DNA damage, mediates transcription silencing in part via phosphorylating and enforcing DSB accumulation of the histone methyltransferase EHMT2. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1). |
| Protein Name | Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1bMinibrain-Related KinaseMirk Protein Kinase |
| Cellular Localisation | NucleusNucleolusChromosomeLocalizes To Sites Of Double-Strand Breaks (Dsbs) Following Dna Damage |
| Alternative Antibody Names | Anti-Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1b antibodyAnti-Minibrain-Related Kinase antibodyAnti-Mirk Protein Kinase antibodyAnti-DYRK1B antibodyAnti-MIRK antibody |
Information sourced from Uniprot.org
