• Western blot analysis of lysates from Jurkat cells, using DYR1B Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of the lysates from COLO205 cells using DYR1B antibody.
  • Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100 (4°C overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.

Anti-DYRK1B antibody (331-380 aa) (STJ92801)

SKU:
STJ92801

£48.00 - £252.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Dual specificity tyrosine-phosphorylation-regulated kinase 1B (331-380 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DYRK1B
Gene ID: 9149
Uniprot ID: DYR1B_HUMAN
Immunogen Region: 331-380 aa
Specificity: Dyrk1B Polyclonal Antibody detects endogenous levels of Dyrk1B protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human DYR1B at the amino acid range 331-380
Post Translational Modifications Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization.
Function Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Plays an essential role in ribosomal DNA (rDNA) double-strand break repair and rDNA copy number maintenance. During DNA damage, mediates transcription silencing in part via phosphorylating and enforcing DSB accumulation of the histone methyltransferase EHMT2. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1).
Protein Name Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1b
Minibrain-Related Kinase
Mirk Protein Kinase
Cellular Localisation Nucleus
Nucleolus
Chromosome
Localizes To Sites Of Double-Strand Breaks (Dsbs) Following Dna Damage
Alternative Antibody Names Anti-Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1b antibody
Anti-Minibrain-Related Kinase antibody
Anti-Mirk Protein Kinase antibody
Anti-DYRK1B antibody
Anti-MIRK antibody

Information sourced from Uniprot.org

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