• Western blot analysis of lysates from HepG2 cells, using DYR1A Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of HepG2 cells using Dyrk1A Polyclonal Antibody diluted at 1：500 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).
  • Immunofluorescence analysis of HepG2 cells, using DYR1A Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using Dyrk1A Polyclonal Antibody diluted at 1：500 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).

Anti-DYRK1A antibody (21-70 aa) (STJ92800)

SKU:
STJ92800

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Dual specificity tyrosine-phosphorylation-regulated kinase 1A (21-70 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DYRK1A
Gene ID: 1859
Uniprot ID: DYR1A_HUMAN
Immunogen Region: 21-70 aa
Specificity: Dyrk1A Polyclonal Antibody detects endogenous levels of Dyrk1A protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human DYR1A at the amino acid range 21-70
Post Translational Modifications Autophosphorylated on numerous tyrosine residues. Can also autophosphorylate on serine and threonine residues (in vitro).
Function Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Plays an important role in double-strand breaks (DSBs) repair following DNA damage. Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits p53/TP53 activity and apoptosis. Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434'.
Protein Name Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1a
Dual Specificity Yak1-Related Kinase
Hp86
Protein Kinase Minibrain Homolog
Mnbh
Hmnb
Database Links Reactome: R-HSA-1538133
Cellular Localisation Nucleus
Nucleus Speckle
Alternative Antibody Names Anti-Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1a antibody
Anti-Dual Specificity Yak1-Related Kinase antibody
Anti-Hp86 antibody
Anti-Protein Kinase Minibrain Homolog antibody
Anti-Mnbh antibody
Anti-Hmnb antibody
Anti-DYRK1A antibody
Anti-DYRK antibody
Anti-MNB antibody
Anti-MNBH antibody

Information sourced from Uniprot.org

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