| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Cytoplasmic dynein 1 intermediate chain 2 for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DYNC1I2 |
| Gene ID: | 1781 |
| Uniprot ID: | DC1I2_HUMAN |
| Specificity: | DC1I2 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Function | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes. |
| Protein Name | Cytoplasmic Dynein 1 Intermediate Chain 2Cytoplasmic Dynein Intermediate Chain 2Dynein Intermediate Chain 2 - CytosolicDh Ic-2 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2132295Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-2565942Reactome: R-HSA-3371497Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-5663220Reactome: R-HSA-6807878Reactome: R-HSA-6811436Reactome: R-HSA-68877Reactome: R-HSA-8854518Reactome: R-HSA-9609690Reactome: R-HSA-9646399Reactome: R-HSA-9648025 |
| Cellular Localisation | CytoplasmCytoskeletonDetected In The Cytoplasm Of Pachytene SpermatocytesLocalizes To The Manchette In Elongating Spermatids |
| Alternative Antibody Names | Anti-Cytoplasmic Dynein 1 Intermediate Chain 2 antibodyAnti-Cytoplasmic Dynein Intermediate Chain 2 antibodyAnti-Dynein Intermediate Chain 2 - Cytosolic antibodyAnti-Dh Ic-2 antibodyAnti-DYNC1I2 antibodyAnti-DNCI2 antibodyAnti-DNCIC2 antibody |
Information sourced from Uniprot.org
