Anti-DWORF antibody (Full Length) (STJ500801)

SKU:
STJ500801-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DWORF (Full Length) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:2, 500-1:5, 000
ELISA: 1:50, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Strit1Uniprot ID=DWORF_MOUSE"
Immunogen Region: Full Length
Immunogen: Synththetic peptide corresponding to full length Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF protein.
Tissue Specificity Highly expressed in heart (at protein level). Detected in heart and soleus, a postural muscle group of the hindlimb containing the highest enrichment of slow-twitch muscle fibers. Also expressed in diaphragm, which contains some slow-twitch fibers. Not detected in the quadriceps, a fast-twitch muscle group, or in cardiac atrial muscle. Not expressed in the prenatal heart but gradually increases in abundance postnatally.
Function Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity. Does not directly stimulate SERCA pump activity. Enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN).
Protein Name Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase Regulator Dworf
Serca Regulator Dworf
Dwarf Open Reading Frame
Dworf
Small Transmembrane Regulator Of Ion Transport 1
Cellular Localisation Sarcoplasmic Reticulum Membrane
Single-Pass Membrane Protein
Alternative Antibody Names Anti-Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase Regulator Dworf antibody
Anti-Serca Regulator Dworf antibody
Anti-Dwarf Open Reading Frame antibody
Anti-Dworf antibody
Anti-Small Transmembrane Regulator Of Ion Transport 1 antibody
Anti-Strit1 antibody

Information sourced from Uniprot.org

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