• Western blot analysis of K562 cells using Dvl-2 Polyclonal Antibody

Anti-DVL2 antibody (670-750 aa) (STJ92789)

SKU:
STJ92789

Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Segment polarity protein dishevelled homolog DVL-2 (670-750 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DVL2
Gene ID: 1856
Uniprot ID: DVL2_HUMAN
Immunogen Region: 670-750 aa
Specificity: Dvl-2 Polyclonal Antibody detects endogenous levels of Dvl-2 protein.
Immunogen: Synthesized peptide derived from Dvl-2 at the amino acid range 670-750
Function Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.
Protein Name Segment Polarity Protein Dishevelled Homolog Dvl-2
Dishevelled-2
Dsh Homolog 2
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-201688
Reactome: R-HSA-2028269
Reactome: R-HSA-4086400
Reactome: R-HSA-4608870
Reactome: R-HSA-4641258
Reactome: R-HSA-4641262
Reactome: R-HSA-5099900
Reactome: R-HSA-5368598
Reactome: R-HSA-5663220
Reactome: R-HSA-8856825
Reactome: R-HSA-8856828
Reactome: R-HSA-9673324
Cellular Localisation Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cytoplasm
Cytosol
Cytoplasmic Vesicle
Nucleus
Localizes At The Cell Membrane Upon Interaction With Frizzled Family Members And Promotes Their Internalization
Localizes To Cytoplasmic Puncta
Interaction With Foxk1 And Foxk2 Induces Nuclear Translocation
Alternative Antibody Names Anti-Segment Polarity Protein Dishevelled Homolog Dvl-2 antibody
Anti-Dishevelled-2 antibody
Anti-Dsh Homolog 2 antibody
Anti-DVL2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance