| Host: | Rabbit |
| Applications: | IF |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-DVL2 (600-736) is suitable for use in Immunofluorescence research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | IF/ICC 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DVL2 |
| Gene ID: | 1856 |
| Uniprot ID: | DVL2_HUMAN |
| Immunogen Region: | 600-736 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 600-736 of human DVL2 (NP_004413.1). |
| Immunogen Sequence: | GAGRTGRPEERAPESKSGSG SESEPSSRGGSLRRGGEASG TSDGGPPPSRGSTGGAPNLR AHPGLHPYGPPPGMALPYNP MMVVMMPPPPPPVPPAVQPP G |
| Post Translational Modifications | Phosphorylated by CSNK1D. WNT3A induces DVL2 phosphorylation by CSNK1E and MARK kinases. |
| Function | Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. |
| Protein Name | Segment Polarity Protein Dishevelled Homolog Dvl-2Dishevelled-2Dsh Homolog 2 |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-201688Reactome: R-HSA-2028269Reactome: R-HSA-4086400Reactome: R-HSA-4608870Reactome: R-HSA-4641258Reactome: R-HSA-4641262Reactome: R-HSA-5099900Reactome: R-HSA-5368598Reactome: R-HSA-5663220Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-9673324 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytosolCytoplasmic VesicleNucleusLocalizes At The Cell Membrane Upon Interaction With Frizzled Family Members And Promotes Their InternalizationLocalizes To Cytoplasmic PunctaInteraction With Foxk1 And Foxk2 Induces Nuclear Translocation |
| Alternative Antibody Names | Anti-Segment Polarity Protein Dishevelled Homolog Dvl-2 antibodyAnti-Dishevelled-2 antibodyAnti-Dsh Homolog 2 antibodyAnti-DVL2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
