| Host: | Rabbit |
| Applications: | IF/ICC/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DVL2 |
| Gene ID: | 1856 |
| Uniprot ID: | DVL2_HUMAN |
| Immunogen Region: | 600-736 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 600-700 of human DVL2 (NP_004413.1). |
| Immunogen Sequence: | GAGRTGRPEERAPESKSGSG SESEPSSRGGSLRRGGEASG TSDGGPPPSRGSTGGAPNLR AHPGLHPYGPPPGMALPYNP MMVVMMPPPPPPVPPAVQPP G |
| Post Translational Modifications | Phosphorylated by CSNK1D. WNT3A induces DVL2 phosphorylation by CSNK1E and MARK kinases. Ubiquitinated via 'Lys-63'-linked polyubiquitin chains.leading to its autophagy-mediated degradation. |
| Function | Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. |
| Protein Name | Segment Polarity Protein Dishevelled Homolog Dvl-2 Dishevelled-2 Dsh Homolog 2 |
| Database Links | Reactome: R-HSA-201681 Reactome: R-HSA-201688 Reactome: R-HSA-2028269 Reactome: R-HSA-4086400 Reactome: R-HSA-4608870 Reactome: R-HSA-4641258 Reactome: R-HSA-4641262 Reactome: R-HSA-5099900 Reactome: R-HSA-5368598 Reactome: R-HSA-5663220 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 Reactome: R-HSA-9673324 |
| Cellular Localisation | Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Cytoplasm Cytosol Cytoplasmic Vesicle Nucleus Localizes At The Cell Membrane Upon Interaction With Frizzled Family Members And Promotes Their Internalization Localizes To Cytoplasmic Puncta Interaction With Foxk1 And Foxk2 Induces Nuclear Translocation |
| Alternative Antibody Names | Anti-Segment Polarity Protein Dishevelled Homolog Dvl-2 antibody Anti-Dishevelled-2 antibody Anti-Dsh Homolog 2 antibody Anti-DVL2 antibody |
Information sourced from Uniprot.org