| Host: | Rabbit |
| Applications: | IF/ICC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DVL2 |
| Gene ID: | 1856 |
| Uniprot ID: | DVL2_HUMAN |
| Immunogen Region: | 1-240 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human DVL2 (NP_004413.1). |
| Immunogen Sequence: | MAGSSTGGGGVGETKVIYHL DEEETPYLVKIPVPAERITL GDFKSVLQRPAGAKYFFKSM DQDFGVVKEEISDDNARLPC FNGRVVSWLVSSDNPQPEMA PPVHEPRAELAPPAPPLPPL PPERTSGIGDSRPPSFHPNV SSSHENLEPETETESVVSLR RERPRRRDSSEHGAGGHRTG GPSRLERHLAGYESSSTLMT SELESTSLGDSDEEDTMSRF SSSTEQSSASRLLKRHRRR |
| Post Translational Modifications | Phosphorylated by CSNK1D. WNT3A induces DVL2 phosphorylation by CSNK1E and MARK kinases. Ubiquitinated via 'Lys-63'-linked polyubiquitin chains.leading to its autophagy-mediated degradation. |
| Function | Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. |
| Protein Name | Segment Polarity Protein Dishevelled Homolog Dvl-2Dishevelled-2Dsh Homolog 2 |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-201688Reactome: R-HSA-2028269Reactome: R-HSA-4086400Reactome: R-HSA-4608870Reactome: R-HSA-4641258Reactome: R-HSA-4641262Reactome: R-HSA-5099900Reactome: R-HSA-5368598Reactome: R-HSA-5663220Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-9673324 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytosolCytoplasmic VesicleNucleusLocalizes At The Cell Membrane Upon Interaction With Frizzled Family Members And Promotes Their InternalizationLocalizes To Cytoplasmic PunctaInteraction With Foxk1 And Foxk2 Induces Nuclear Translocation |
| Alternative Antibody Names | Anti-Segment Polarity Protein Dishevelled Homolog Dvl-2 antibodyAnti-Dishevelled-2 antibodyAnti-Dsh Homolog 2 antibodyAnti-DVL2 antibody |
Information sourced from Uniprot.org
