| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Rat/Dog/Pig/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-DUSP6/MKP3 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 26kDa band observed in Mouse and Rat Heart lysates and 40kDa plus 26kDa bands observed in Human and Pig Heart lysates (calculated MW of 42.3kDa according to NP_001937.2 and 26. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | DUSP6 |
| Gene ID: | 1848 |
| Uniprot ID: | DUS6_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_001937.2; NP_073143.2 |
| Specificity: | This antibody is expected to recognize both reported isoforms (NP_001937.2; NP_073143.2). |
| Immunogen Sequence: | PSNQNVYQVDSLQST |
| Function | Inactivates MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain. Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors. |
| Protein Name | Dual Specificity Protein Phosphatase 6Dual Specificity Protein Phosphatase Pyst1Mitogen-Activated Protein Kinase Phosphatase 3Map Kinase Phosphatase 3Mkp-3 |
| Database Links | Reactome: R-HSA-112409Reactome: R-HSA-202670Reactome: R-HSA-5675221Reactome: R-HSA-9652817 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase 6 antibodyAnti-Dual Specificity Protein Phosphatase Pyst1 antibodyAnti-Mitogen-Activated Protein Kinase Phosphatase 3 antibodyAnti-Map Kinase Phosphatase 3 antibodyAnti-Mkp-3 antibodyAnti-DUSP6 antibodyAnti-MKP3 antibodyAnti-PYST1 antibody |
Information sourced from Uniprot.org