Anti-DUSP6 antibody (282-381) [S0MR] (STJ11101230)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal DUSP6 (282-381) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S0MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000IHC-P:1:200-1:800ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DUSP6 |
| Gene ID | 1848 |
| Uniprot ID | DUS6_HUMAN |
| Immunogen Region | 282-381 |
| Immunogen Sequence | ARGKNCGVLVHCLAGISRSV TVTVAYLMQKLNLSMNDAYD IVKMKKSNISPNFNFMGQLL DFERTLGLSSPCDNRVPAQQ LYFTTPSNQNVYQVDSLQST |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 282-381 of human DUSP6 (Q16828). |
Additional Info
| Tissue Specificity | Expressed in keratinocytes (at protein level). |
| Post Translational Modifications | Ubiquitinated by the SCF(FBXO31) complex, leading to its proteasomal degradation. |
| Function | Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain. Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors. |
| Protein Name | Dual Specificity Protein Phosphatase 6Dual Specificity Protein Phosphatase Pyst1Mitogen-Activated Protein Kinase Phosphatase 3Map Kinase Phosphatase 3Mkp-3 |
| Database Links | Reactome: R-HSA-112409Reactome: R-HSA-202670Reactome: R-HSA-5675221Reactome: R-HSA-9652817 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase 6 antibodyAnti-Dual Specificity Protein Phosphatase Pyst1 antibodyAnti-Mitogen-Activated Protein Kinase Phosphatase 3 antibodyAnti-Map Kinase Phosphatase 3 antibodyAnti-Mkp-3 antibodyAnti-DUSP6 antibodyAnti-MKP3 antibodyAnti-PYST1 antibody |
Information sourced from Uniprot.org