| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-tRNA-dihydrouridine20 synthase-like (421-470 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DUS2 |
| Gene ID: | 54920 |
| Uniprot ID: | DUS2_HUMAN |
| Immunogen Region: | 421-470 aa |
| Specificity: | DUS2L Polyclonal Antibody detects endogenous levels of DUS2L protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human DUS2L at the amino acid range 421-470 |
| Function | Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U20 in cytoplasmic tRNAs. Activity depends on the presence of guanosine at position 19 in the tRNA substrate. Negatively regulates the activation of EIF2AK2/PKR. |
| Protein Name | Trna-Dihydrouridine(20 Synthase Nad(P+-LikeDihydrouridine Synthase 2Up-Regulated In Lung Cancer Protein 8Urlc8Trna-Dihydrouridine Synthase 2-LikeHdus2 |
| Database Links | Reactome: R-HSA-6782315Reactome: R-HSA-9833482 |
| Cellular Localisation | CytoplasmEndoplasmic ReticulumMainly At The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Trna-Dihydrouridine(20 Synthase Nad(P+-Like antibodyAnti-Dihydrouridine Synthase 2 antibodyAnti-Up-Regulated In Lung Cancer Protein 8 antibodyAnti-Urlc8 antibodyAnti-Trna-Dihydrouridine Synthase 2-Like antibodyAnti-Hdus2 antibodyAnti-DUS2 antibodyAnti-DUS2L antibody |
Information sourced from Uniprot.org