| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DTX2 |
| Gene ID: | 113878 |
| Uniprot ID: | DTX2_HUMAN |
| Immunogen Region: | 1-280 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human DTX2 (NP_065943.2). |
| Immunogen Sequence: | MAMAPSPSLVQVYTSPAAVA VWEWQDGLGTWHPYSATVCS FIEQQFVQQKGQRFGLGSLA HSIPLGQADPSLAPYIIDLP SWTQFRQDTGTMRAVRRHLF PQHSAPGRGVVWEWLSDDGS WTAYEASVCDYLEQQVARGN QLVDLAPLGYNYTVNYTTHT QTNKTSSFCRSVRRQAGPPY PVTTIIAPPGHTGVACSCHQ CLSGSRTGPVSGRYRHSMTN LPAYPVPQHPPHRTASVFG |
| Function | Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. |
| Protein Name | Probable E3 Ubiquitin-Protein Ligase Dtx2Protein Deltex-2Deltex2Hdtx2Ring Finger Protein 58Ring-Type E3 Ubiquitin Transferase Dtx2 |
| Database Links | Reactome: R-HSA-2122948 |
| Cellular Localisation | CytoplasmNucleusPredominantly CytoplasmicPartially Nuclear |
| Alternative Antibody Names | Anti-Probable E3 Ubiquitin-Protein Ligase Dtx2 antibodyAnti-Protein Deltex-2 antibodyAnti-Deltex2 antibodyAnti-Hdtx2 antibodyAnti-Ring Finger Protein 58 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Dtx2 antibodyAnti-DTX2 antibodyAnti-KIAA1528 antibodyAnti-RNF58 antibody |
Information sourced from Uniprot.org