| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Desmoglein-3 (50-615) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DSG3 |
| Gene ID: |
1830 |
| Uniprot ID: |
DSG3_HUMAN |
| Immunogen Region: |
50-615 |
| Immunogen: |
Recombinant Protein corresponding to a sequence within amino acids 50-615 of human DSG3/Desmoglein-3 (NP_001935.2). |
| Immunogen Sequence: |
EWVKFAKPCREGEDNSKRNP IAKITSDYQATQKITYRISG VGIDQPPFGIFVVDKNTGDI NITAIVDREETPSFLITCRA LNAQGLDVEKPLILTVKILD INDNPPVFSQQIFMGEIEEN SASNSLVMILNATDADEPNH LNSKIAFKIVSQEPAGTPMF LLSRNTGEVRTLTNSLDREQ ASSYRLVVSGADKDGEGLST QCECNIKVKDVNDNFPMFRD SQYSARIEENILSSELLRF |
| Tissue Specificity | Epidermis, tongue, tonsil, esophagus and carcinomas. Expressed in skin and mucosa (at protein level). |
| Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. |
| Protein Name | Desmoglein-3130 Kda Pemphigus Vulgaris AntigenPvaCadherin Family Member 6 |
| Database Links | Reactome: R-HSA-351906Reactome: R-HSA-6805567Reactome: R-HSA-6809371 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionDesmosome |
| Alternative Antibody Names | Anti-Desmoglein-3 antibodyAnti-130 Kda Pemphigus Vulgaris Antigen antibodyAnti-Pva antibodyAnti-Cadherin Family Member 6 antibodyAnti-DSG3 antibodyAnti-CDHF6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
